Melissa C. Skala Biography Publications JoVE Articles Melissa C. Skala has not added a biography. If you are Melissa C. Skala and would like to personalize this page please email our Author Liaison for assistance. Publications Perspectives on Label-free Microscopy of Heterogeneous and Dynamic Biological Systems Journal of Biomedical Optics. Dec, 2025 | Pubmed ID: 38434231 Targeting DNMT3A-mediated Oxidative Phosphorylation to Overcome Ibrutinib Resistance in Mantle Cell Lymphoma Cell Reports. Medicine. Mar, 2024 | Pubmed ID: 38554704 Autofluorescence is a Biomarker of Neural Stem Cell Activation State Cell Stem Cell. Apr, 2024 | Pubmed ID: 38521057 Development of a Multilayer Fetal Membrane Material Model Calibrated Using Bulge Inflation Mechanical Tests Journal of the Mechanical Behavior of Biomedical Materials. Feb, 2024 | Pubmed ID: 38160642 Preclinical Models of Anal Cancer Combined-Modality Therapy The Journal of Surgical Research. Feb, 2024 | Pubmed ID: 37864962 Author Correction: Microphysiological Model Reveals the Promise of Memory-like Natural Killer Cell Immunotherapy for HIV Cancer Nature Communications. Nov, 2023 | Pubmed ID: 37949872 Label-free Optical Imaging and Sensing for Quality Control of Stem Cell Manufacturing Current Opinion in Biomedical Engineering. Mar, 2023 | Pubmed ID: 37885458 Microphysiological Model Reveals the Promise of Memory-like Natural Killer Cell Immunotherapy for HIV Cancer Nature Communications. Oct, 2023 | Pubmed ID: 37865647 Griddient: a Microfluidic Array to Generate Reconfigurable Gradients On-demand for Spatial Biology Applications Communications Biology. Sep, 2023 | Pubmed ID: 37689746 Microfluidic Device with Reconfigurable Spatial Temporal Gradients Reveals Plastic Astrocyte Response to Stroke and Reperfusion Lab on a Chip. Sep, 2023 | Pubmed ID: 37448230 Light-sheet Autofluorescence Lifetime Imaging with a Single-photon Avalanche Diode Array Journal of Biomedical Optics. Jun, 2023 | Pubmed ID: 37351197 Optical Coherence Tomography of Human Fetal Membrane Sub-layers During Loading Biomedical Optics Express. Jun, 2023 | Pubmed ID: 37342693 Microphysiological Head and Neck Cancer Model Identifies Novel Role of Lymphatically Secreted Monocyte Migration Inhibitory Factor in Cancer Cell Migration and Metabolism Biomaterials. Apr, 2023 | Pubmed ID: 37178589 Single Cell Metabolic Imaging of Tumor and Immune Cells in Melanoma Bearing Mice Frontiers in Oncology. 2023 | Pubmed ID: 37020875 Inflammatory CD4/CD8 Double-positive Human T Cells Arise from Reactive CD8 T Cells and Are Sufficient to Mediate GVHD Pathology Science Advances. Mar, 2023 | Pubmed ID: 36961891 Light Sheet Autofluorescence Lifetime Imaging with a Single Photon Avalanche Diode Array BioRxiv : the Preprint Server for Biology. Feb, 2023 | Pubmed ID: 36778488 Autofluorescence Lifetime Imaging Classifies Human Lymphocyte Activation and Subtype BioRxiv : the Preprint Server for Biology. Jan, 2023 | Pubmed ID: 36747690 Touch-free Optical Technologies to Streamline the Production of T Cell Therapies Current Opinion in Biomedical Engineering. Mar, 2023 | Pubmed ID: 36642996 Prostate Cancer Cells Demonstrate Unique Metabolism and Substrate Adaptability Acutely After Androgen Deprivation Therapy The Prostate. Dec, 2022 | Pubmed ID: 35980831 Treatment Inequity: Examining the Influence of Non-Hispanic Black Race and Ethnicity on Pancreatic Cancer Care and Survival in Wisconsin WMJ : Official Publication of the State Medical Society of Wisconsin. Jul, 2022 | Pubmed ID: 35857681 Autofluorescence Lifetime Assay of a Photoreceptor Stimulus Response in Mouse Retina and Human Retinal Organoids Biomedical Optics Express. Jun, 2022 | Pubmed ID: 35781966 Inhibition of B-cell Lymphoma 2 Family Proteins Alters Optical Redox Ratio, Mitochondrial Polarization, and Cell Energetics Independent of Cell State Journal of Biomedical Optics. May, 2022 | Pubmed ID: 35643815 Label-Free Imaging to Track Reprogramming of Human Somatic Cells GEN Biotechnology. Apr, 2022 | Pubmed ID: 35586336 Innate Immune Cell Response to Host-parasite Interaction in a Human Intestinal Tissue Microphysiological System Science Advances. May, 2022 | Pubmed ID: 35544643 Impact of Baseline Culture Conditions Of cancer Organoids when Determining Therapeutic Response and Tumor Heterogeneity Scientific Reports. Mar, 2022 | Pubmed ID: 35338174 Microphysiological Model of Renal Cell Carcinoma to Inform Anti-angiogenic Therapy Biomaterials. 04, 2022 | Pubmed ID: 35299086 Technologies to Assess Drug Response and Heterogeneity in Patient-Derived Cancer Organoids Annual Review of Biomedical Engineering. Jun, 2022 | Pubmed ID: 35259932 In Vivo Fluorescence Lifetime Imaging of Macrophage Intracellular Metabolism During Wound Responses in Zebrafish ELife. Feb, 2022 | Pubmed ID: 35200139 Interactions with Stromal Cells Promote a More Oxidized Cancer Cell Redox State in Pancreatic Tumors Science Advances. Jan, 2022 | Pubmed ID: 35061540 Maturation- and Degeneration-dependent Articular Cartilage Metabolism Via Optical Redox Ratio Imaging Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Aug, 2022 | Pubmed ID: 34792214 Breast Cancer Immunotherapy: Current Biomarkers and the Potential of Assays Current Opinion in Biomedical Engineering. Mar, 2021 | Pubmed ID: 34901585 Volumetric Growth Tracking of Patient-derived Cancer Organoids Using Optical Coherence Tomography Biomedical Optics Express. Jul, 2021 | Pubmed ID: 34457380 Label-free Imaging for Quality Control of Cardiomyocyte Differentiation Nature Communications. Jul, 2021 | Pubmed ID: 34321477 Recent Innovations in Fluorescence Lifetime Imaging Microscopy for Biology and Medicine Journal of Biomedical Optics. Jul, 2021 | Pubmed ID: 34247457 Optical Coherence Tomography Angiography in the Thirteen-Lined Ground Squirrel Translational Vision Science & Technology. Jul, 2021 | Pubmed ID: 34232271 Extracellular PH Affects the Fluorescence Lifetimes of Metabolic Co-factors Journal of Biomedical Optics. May, 2021 | Pubmed ID: 34032035 Intravital Metabolic Autofluorescence Imaging Captures Macrophage Heterogeneity Across Normal and Cancerous Tissue Frontiers in Bioengineering and Biotechnology. 2021 | Pubmed ID: 33959597 Autofluorescence Imaging of Treatment Response in Neuroendocrine Tumor Organoids Cancers. Apr, 2021 | Pubmed ID: 33919802 The NIH Somatic Cell Genome Editing Program Nature. Apr, 2021 | Pubmed ID: 33828315 Patient-derived Cancer Organoid Tracking with Wide-field One-photon Redox Imaging to Assess Treatment Response Journal of Biomedical Optics. Mar, 2021 | Pubmed ID: 33754540 Microfluidic Tumor-on-a-chip Model to Evaluate the Role of Tumor Environmental Stress on NK Cell Exhaustion Science Advances. Feb, 2021 | Pubmed ID: 33597234 Carbomer-based Adjuvant Elicits CD8 T-cell Immunity by Inducing a Distinct Metabolic State in Cross-presenting Dendritic Cells PLoS Pathogens. 01, 2021 | Pubmed ID: 33444400 Classification of T-cell Activation Via Autofluorescence Lifetime Imaging Nature Biomedical Engineering. 01, 2021 | Pubmed ID: 32719514 Microfluidic Tumor-on-a-Chip Model to Study Tumor Metabolic Vulnerability International Journal of Molecular Sciences. Nov, 2020 | Pubmed ID: 33260673 Autofluorescence Imaging of 3D Tumor-Macrophage Microscale Cultures Resolves Spatial and Temporal Dynamics of Macrophage Metabolism Cancer Research. Dec, 2020 | Pubmed ID: 33093167 Adaptable Pulsatile Flow Generated from Stem Cell-derived Cardiomyocytes Using Quantitative Imaging-based Signal Transduction Lab on a Chip. Oct, 2020 | Pubmed ID: 33048070 A Bioengineered Organotypic Prostate Model for the Study of Tumor Microenvironment-induced Immune Cell Activation Integrative Biology : Quantitative Biosciences from Nano to Macro. Oct, 2020 | Pubmed ID: 33034643 MEK Activation Modulates Glycolysis and Supports Suppressive Myeloid Cells in TNBC JCI Insight. Aug, 2020 | Pubmed ID: 32634121 Metabolic Heterogeneity in Patient Tumor-Derived Organoids by Primary Site and Drug Treatment Frontiers in Oncology. 2020 | Pubmed ID: 32500020 Label-free Redox Imaging of Patient-derived Organoids Using Selective Plane Illumination Microscopy Biomedical Optics Express. May, 2020 | Pubmed ID: 32499946 Fluorescence Lifetime Imaging Microscopy: Fundamentals and Advances in Instrumentation, Analysis, and Applications Journal of Biomedical Optics. May, 2020 | Pubmed ID: 32406215 Human Tumor-Lymphatic Microfluidic Model Reveals Differential Conditioning of Lymphatic Vessels by Breast Cancer Cells Advanced Healthcare Materials. Feb, 2020 | Pubmed ID: 31894641 Sample Preparation Strategies for High-throughput Mass Spectrometry Imaging of Primary Tumor Organoids Journal of Mass Spectrometry : JMS. Apr, 2020 | Pubmed ID: 31661714 Classifying T Cell Activity in Autofluorescence Intensity Images with Convolutional Neural Networks Journal of Biophotonics. Mar, 2020 | Pubmed ID: 31661592 Development of a Microfluidic Array to Study Drug Response in Breast Cancer Molecules (Basel, Switzerland). Nov, 2019 | Pubmed ID: 31801265 Quantitative Spatial Analysis of Metabolic Heterogeneity Across and Tumor Models Frontiers in Oncology. 2019 | Pubmed ID: 31737571 Tumor-on-a-chip: a Microfluidic Model to Study Cell Response to Environmental Gradients Lab on a Chip. Oct, 2019 | Pubmed ID: 31506657 Effects of Culture Method on Response to EGFR Therapy in Head and Neck Squamous Cell Carcinoma Cells Scientific Reports. Aug, 2019 | Pubmed ID: 31462653 Patient-Derived Cancer Organoid Cultures to Predict Sensitivity to Chemotherapy and Radiation Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2019 | Pubmed ID: 31175091 Photothermal Optical Coherence Tomography of Anti-Angiogenic Treatment in the Mouse Retina Using Gold Nanorods As Contrast Agents Translational Vision Science & Technology. May, 2019 | Pubmed ID: 31131155 Cellular Metabolic Heterogeneity In Vivo Is Recapitulated in Tumor Organoids Neoplasia (New York, N.Y.). Jun, 2019 | Pubmed ID: 31078067 Imaging Intratumoral Metabolic Heterogeneity Nature Biomedical Engineering. May, 2019 | Pubmed ID: 31073174 Evaluating Natural Killer Cell Cytotoxicity Against Solid Tumors Using a Microfluidic Model Oncoimmunology. 2019 | Pubmed ID: 30723584 Redox Imaging and Optical Coherence Tomography of the Respiratory Ciliated Epithelium Journal of Biomedical Optics. Jan, 2019 | Pubmed ID: 30701725 Reproducibility and Staging of 3D Human Retinal Organoids Across Multiple Pluripotent Stem Cell Lines Development (Cambridge, England). Jan, 2019 | Pubmed ID: 30567931 Quantitative Label-Free Imaging of 3D Vascular Networks Self-Assembled in Synthetic Hydrogels Advanced Healthcare Materials. Jan, 2019 | Pubmed ID: 30565891 MTORC1/2 Inhibition As a Therapeutic Strategy for Mutant Cancers Molecular Cancer Therapeutics. Feb, 2019 | Pubmed ID: 30425131 BET Inhibitors Reduce Cell Size and Induce Reversible Cell Cycle Arrest in AML Journal of Cellular Biochemistry. May, 2019 | Pubmed ID: 30417424 Organotypic Microfluidic Breast Cancer Model Reveals Starvation-induced Spatial-temporal Metabolic Adaptations EBioMedicine. Nov, 2018 | Pubmed ID: 30482722 Imaging Melanin Distribution in the Zebrafish Retina Using Photothermal Optical Coherence Tomography Translational Vision Science & Technology. 2018 | Pubmed ID: 30197836 Mutant KRAS Exosomes Alter the Metabolic State of Recipient Colonic Epithelial Cells Cellular and Molecular Gastroenterology and Hepatology. 2018 | Pubmed ID: 29930982 Quantifying Optical Properties with Visible and Near-infrared Optical Coherence Tomography to Visualize Esophageal Microwave Ablation Zones Biomedical Optics Express. Apr, 2018 | Pubmed ID: 29675308 Protein-bound NAD(P)H Lifetime is Sensitive to Multiple Fates of Glucose Carbon Scientific Reports. Apr, 2018 | Pubmed ID: 29615678 Oxidative Stress Via Inhibition of the Mitochondrial Electron Transport and Nrf-2-mediated Anti-oxidative Response Regulate the Cytotoxic Activity of Plumbagin Scientific Reports. Jan, 2018 | Pubmed ID: 29348410 Autofluorescence Imaging Identifies Tumor Cell-cycle Status on a Single-cell Level Journal of Biophotonics. Jan, 2018 | Pubmed ID: 28485124 In Vivo Photothermal Optical Coherence Tomography of Endogenous and Exogenous Contrast Agents in the Eye Scientific Reports. Aug, 2017 | Pubmed ID: 28835698 Functional Optical Imaging of Primary Human Tumor Organoids: Development of a Personalized Drug Screen Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Sep, 2017 | Pubmed ID: 28588148 Metabolic Imaging of Head and Neck Cancer Organoids PloS One. 2017 | Pubmed ID: 28099487 Autofluorescence Flow Sorting of Breast Cancer Cell Metabolism Journal of Biophotonics. Aug, 2017 | Pubmed ID: 27730745
