Jari Yli-Kauhaluoma Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy University of Helsinki Biography Publications Institution JoVE Articles Jari Yli-Kauhaluoma has not added a biography. If you are Jari Yli-Kauhaluoma and would like to personalize this page please email our Author Liaison for assistance. Publications Simple 3D Printed Stainless Steel Microreactors for Online Mass Spectrometric Analysis Heliyon. Jul, 2019 | Pubmed ID: 31312730 Ketamine-induced Regulation of TrkB-GSK3β Signaling is Accompanied by Slow EEG Oscillations and Sedation but is Independent of Hydroxynorketamine Metabolites Neuropharmacology. Oct, 2019 | Pubmed ID: 31251996 Asymmetry in Catalysis by Membrane-bound Pyrophosphatase Demonstrated by a Nonphosphorus Allosteric Inhibitor Science Advances. May, 2019 | Pubmed ID: 31131322 Preparation and Characterization of Dentin Phosphophoryn-Derived Peptide-Functionalized Lignin Nanoparticles for Enhanced Cellular Uptake Small (Weinheim an Der Bergstrasse, Germany). Jun, 2019 | Pubmed ID: 31062448 Pyrazine-Fused Triterpenoids Block the TRPA1 Ion Channel in Vitro and Inhibit TRPA1-Mediated Acute Inflammation in Vivo ACS Chemical Neuroscience. Jun, 2019 | Pubmed ID: 31034197 Structure-Activity Relationships of 1-Benzoylazulenes at the OX and OX Orexin Receptors ChemMedChem. May, 2019 | Pubmed ID: 30892823 Tissue-specific Study Across the Stem Reveals the Chemistry and Transcriptome Dynamics of Birch Bark The New Phytologist. 06, 2019 | Pubmed ID: 30724367 Catalytic, Tunable, One-Step Bismuth(III) Triflate Reaction with Alcohols: Dehydration Versus Dimerization ACS Omega. Aug, 2018 | Pubmed ID: 31459017 Discovery of 12-Thiazole Abietanes As Selective Inhibitors of the Human Metabolic Serine Hydrolase HABHD16A ACS Medicinal Chemistry Letters. Dec, 2018 | Pubmed ID: 30613338 Synthesis and Antiproliferative Activity of Marine Bromotyrosine Purpurealidin I and Its Derivatives Marine Drugs. Dec, 2018 | Pubmed ID: 30513862 Dehydroabietic Oximes Halt Pancreatic Cancer Cell Growth in the G1 Phase Through Induction of P27 and Downregulation of Cyclin D1 Scientific Reports. 10, 2018 | Pubmed ID: 30374056 Azulene-based Compounds for Targeting Orexin Receptors European Journal of Medicinal Chemistry. Sep, 2018 | Pubmed ID: 30077889 Stem Cells Are the Most Sensitive Screening Tool to Identify Toxicity of GATA4-targeted Novel Small-molecule Compounds Archives of Toxicology. 09, 2018 | Pubmed ID: 29987409 Conditioned Reward of Opioids, but Not Psychostimulants, is Impaired in GABA-A Receptor δ Subunit Knockout Mice Basic & Clinical Pharmacology & Toxicology. Nov, 2018 | Pubmed ID: 29781560 Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner Journal of Natural Products. 05, 2018 | Pubmed ID: 29726680 Synthesis of 7β-hydroxy-8-ketone Opioid Derivatives with Antagonist Activity at Mu- and Delta-opioid Receptors European Journal of Medicinal Chemistry. May, 2018 | Pubmed ID: 29649744 Scaffold Hopping from (5-hydroxymethyl) Isophthalates to Multisubstituted Pyrimidines Diminishes Binding Affinity to the C1 Domain of Protein Kinase C PloS One. 2018 | Pubmed ID: 29641588 Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells Planta Medica. Jul, 2018 | Pubmed ID: 29518814 Trisubstituted Barbiturates and Thiobarbiturates: Synthesis and Biological Evaluation As Xanthine Oxidase Inhibitors, Antioxidants, Antibacterial and Anti-proliferative Agents European Journal of Medicinal Chemistry. Jan, 2018 | Pubmed ID: 29223098 Synthesis of Novel Purpurealidin Analogs and Evaluation of Their Effect on the Cancer-relevant Potassium Channel KV10.1 PloS One. 2017 | Pubmed ID: 29220359 Functionalization of Carboxylated Lignin Nanoparticles for Targeted and PH-responsive Delivery of Anticancer Drugs Nanomedicine (London, England). Nov, 2017 | Pubmed ID: 28960138 Nucleophilic Substitution of Hydrogen Facilitated by Quinone Methide Moieties in Benzo[cd]azulen-3-ones Organic Letters. 04, 2017 | Pubmed ID: 28379712 In vitro Evaluation of Biodegradable Lignin-based Nanoparticles for Drug Delivery and Enhanced Antiproliferation Effect in Cancer Cells Biomaterials. 03, 2017 | Pubmed ID: 28081462 Quercetin-Based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin-Resistant Cancer Cells Advanced Healthcare Materials. Feb, 2017 | Pubmed ID: 27943644 Synthesis and Anti-Proliferative Activity of Sulfanyltriazolylnaphthalenols and Sulfanyltriazolylnaphthalene-1,4-diones Archiv Der Pharmazie. Sep, 2016 | Pubmed ID: 27404773 Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo Journal of Natural Products. Feb, 2016 | Pubmed ID: 26915998 Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity Against Leishmania Donovani and Trypanosoma Cruzi Journal of Natural Products. Feb, 2016 | Pubmed ID: 26849852 Synthesis and Biological Evaluation of 2-Aminobenzothiazole and Benzimidazole Analogs Based on the Clathrodin Structure Archiv Der Pharmazie. Feb, 2016 | Pubmed ID: 26709468 Synthesis of 1,3,6-Trisubstituted Azulenes The Journal of Organic Chemistry. Nov, 2015 | Pubmed ID: 26528547 New Derivatives of Dehydroabietic Acid Target Planktonic and Biofilm Bacteria in Staphylococcus Aureus and Effectively Disrupt Bacterial Membrane Integrity European Journal of Medicinal Chemistry. Sep, 2015 | Pubmed ID: 26241878 Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts PloS One. 2015 | Pubmed ID: 26075720 Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells Through Lead Development PloS One. 2015 | Pubmed ID: 25965345 A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides Journal of Medicinal Chemistry. Jun, 2015 | Pubmed ID: 25906200 Mass-tag Enhanced Immuno-laser Desorption/ionization Mass Spectrometry for Sensitive Detection of Intact Protein Antigens Analytical Chemistry. May, 2015 | Pubmed ID: 25867450 Synthesis and Biological Evaluation of 2-arylbenzimidazoles Targeting Leishmania Donovani Bioorganic & Medicinal Chemistry Letters. May, 2015 | Pubmed ID: 25827525 C1 Domain-targeted Isophthalates As Protein Kinase C Modulators: Structure-based Design, Structure-activity Relationships and Biological Activities Biochemical Society Transactions. Dec, 2014 | Pubmed ID: 25399568 Betulin Derivatives Impair Leishmania Braziliensis Viability and Host-parasite Interaction Bioorganic & Medicinal Chemistry. Nov, 2014 | Pubmed ID: 25240731 Exploring Marine Resources for Bioactive Compounds Planta Medica. Sep, 2014 | Pubmed ID: 25203732 Screening and Characterisation of Antimicrobial Properties of Semisynthetic Betulin Derivatives PloS One. 2014 | Pubmed ID: 25032708 Discovery of Triterpenoids As Reversible Inhibitors of α/β-hydrolase Domain Containing 12 (ABHD12) PloS One. 2014 | Pubmed ID: 24879289 (+)-Dehydroabietic Acid, an Abietane-type Diterpene, Inhibits Staphylococcus Aureus Biofilms in Vitro International Journal of Molecular Sciences. Jun, 2013 | Pubmed ID: 23739682 The C1 Domain-targeted Isophthalate Derivative HMI-1b11 Promotes Neurite Outgrowth and GAP-43 Expression Through PKCα Activation in SH-SY5Y Cells Pharmacological Research. Jul, 2013 | Pubmed ID: 23643828 Interaction Between Retinoid Acid Receptor-related Orphan Receptor Alpha (RORA) and Neuropeptide S Receptor 1 (NPSR1) in Asthma PloS One. 2013 | Pubmed ID: 23565190 Tricyclic Benzo[cd]azulenes Selectively Inhibit Activities of Pim Kinases and Restrict Growth of Epstein-Barr Virus-transformed Cells PloS One. 2013 | Pubmed ID: 23405147 Albumin Stimulates the Activity of the Human UDP-glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the Effects Are Enzyme and Substrate Dependent PloS One. 2013 | Pubmed ID: 23372764 UDP-glucuronic Acid Binds First and the Aglycone Substrate Binds Second to Form a Ternary Complex in UGT1A9-catalyzed Reactions, in Both the Presence and Absence of Bovine Serum Albumin Drug Metabolism and Disposition: the Biological Fate of Chemicals. Nov, 2012 | Pubmed ID: 22912433 Design, Synthesis, and Biological Activity of Urea Derivatives As Anaplastic Lymphoma Kinase Inhibitors ChemMedChem. Sep, 2011 | Pubmed ID: 21721129 C1 Domain-targeted Isophthalate Derivatives Induce Cell Elongation and Cell Cycle Arrest in HeLa Cells PloS One. 2011 | Pubmed ID: 21629792 Current Status and Future Prospects of C1 Domain Ligands As Drug Candidates Current Topics in Medicinal Chemistry. 2011 | Pubmed ID: 21513495 Synthesis and Evaluation of Library of Betulin Derivatives Against the Botulinum Neurotoxin A Protease Bioorganic & Medicinal Chemistry Letters. Apr, 2011 | Pubmed ID: 21421315 Synthesis and Tautomerization of Benzo[cd]azulen-3-ones Organic Letters. Apr, 2011 | Pubmed ID: 21370863 Polyketide Derivatives Active Against Botrytis Cinerea in Gerbera Hybrida Planta. Jan, 2011 | Pubmed ID: 20878179 Design and Synthesis of 2-arylbenzimidazoles and Evaluation of Their Inhibitory Effect Against Chlamydia Pneumoniae Journal of Medicinal Chemistry. Nov, 2010 | Pubmed ID: 20932010 HIV-1 Tat-peptide Inhibits Protein Kinase C and Protein Kinase A Through Substrate Competition European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Aug, 2010 | Pubmed ID: 20433920 Anti-leishmanial Activity of Betulin Derivatives The Journal of Antibiotics. Mar, 2010 | Pubmed ID: 20139867 Synthesis and Anti-leishmanial Activity of Heterocyclic Betulin Derivatives Bioorganic & Medicinal Chemistry. Feb, 2010 | Pubmed ID: 20116263 Glucuronidation of Psilocin and 4-hydroxyindole by the Human UDP-glucuronosyltransferases Drug Metabolism and Disposition: the Biological Fate of Chemicals. Mar, 2010 | Pubmed ID: 20007669 The Binding of Synthetic Retinoids to Lipocalin Beta-lactoglobulins Journal of Medicinal Chemistry. Jan, 2010 | Pubmed ID: 19938842 Brain-derived Neurotrophic Factor Controls Activity-dependent Maturation of CA1 Synapses by Downregulating Tonic Activation of Presynaptic Kainate Receptors The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2009 | Pubmed ID: 19741136 Synthesis, Structure Characterization, and Enzyme Screening of Clenbuterol Glucuronides European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jul, 2009 | Pubmed ID: 19447177 Design, Synthesis, and Biological Activity of Isophthalic Acid Derivatives Targeted to the C1 Domain of Protein Kinase C Journal of Medicinal Chemistry. Jul, 2009 | Pubmed ID: 19438240 Synthesis and Characterization of Hydroxylated Mesocarb Metabolites for Doping Control Archiv Der Pharmazie. Apr, 2009 | Pubmed ID: 19340833 Acetylcholinesterase Inhibitory Guided Fractionation of Melissa Officinalis L Bioorganic & Medicinal Chemistry. Jan, 2009 | Pubmed ID: 19070498 A New Insight into Solid-state Conformation of Macrolide Antibiotics Bioorganic & Medicinal Chemistry. Jan, 2008 | Pubmed ID: 17936632 Stereochemical and Steric Control of the UDP-glucuronosyltransferase-catalyzed Conjugation Reaction: a Rational Approach for the Design of Inhibitors for the Human UGT2B7 ChemMedChem. Dec, 2007 | Pubmed ID: 17943712 Eudismic Analysis of Tricyclic Sesquiterpenoid Alcohols: Lead Structures for the Design of Potent Inhibitors of the Human UDP-glucuronosyltransferase 2B7 Bioorganic Chemistry. Oct, 2007 | Pubmed ID: 17706742 Regioselective Sulfonation of Dopamine by SULT1A3 in Vitro Provides a Molecular Explanation for the Preponderance of Dopamine-3-O-sulfate in Human Blood Circulation Biochemical Pharmacology. Aug, 2007 | Pubmed ID: 17548063 Potent Inhibitors of the Human UDP-glucuronosyltransferase 2B7 Derived from the Sesquiterpenoid Alcohol Longifolol ChemMedChem. Jun, 2007 | Pubmed ID: 17479992 Isoform-selective Inhibition of the Human UDP-glucuronosyltransferase 2B7 by Isolongifolol Derivatives Journal of Medicinal Chemistry. May, 2007 | Pubmed ID: 17474732 Stereoselective Aza Diels-Alder Reaction on Solid Phase: a Facile Synthesis of Hexahydrocinnoline Derivatives Journal of Combinatorial Chemistry. Mar-Apr, 2007 | Pubmed ID: 17348732 Assessing the Data Quality in Predictive Toxicology Using a Panel of Cell Lines and Cytotoxicity Assays Analytical Biochemistry. Mar, 2007 | Pubmed ID: 17266913 Microplate Screening Assay for Binding of Ligands to Bovine or Reindeer Beta-lactoglobulins Journal of Biochemical and Biophysical Methods. Aug, 2006 | Pubmed ID: 16766039 Morphine, Oxycodone, Methadone and Its Enantiomers in Different Models of Nociception in the Rat Anesthesia and Analgesia. Jun, 2006 | Pubmed ID: 16717324 Pharmacological Properties of the Ubiquitous Natural Product Betulin European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Sep, 2006 | Pubmed ID: 16716572 Solid-phase Synthesis of Pyrazolopyridines from Polymer-bound Alkyne and Azomethine Imines Journal of Combinatorial Chemistry. May-Jun, 2006 | Pubmed ID: 16677003 Stereochemical Sensitivity of the Human UDP-glucuronosyltransferases 2B7 and 2B17 Journal of Medicinal Chemistry. Mar, 2006 | Pubmed ID: 16509597 Methadone Increases Intracellular Calcium in SH-SY5Y and SH-EP1-halpha7 Cells by Activating Neuronal Nicotinic Acetylcholine Receptors Journal of Neurochemistry. Sep, 2005 | Pubmed ID: 16000156 Microwave-assisted Synthesis of Imidazoles: Reaction of P-toluenesulfonylmethyl Isocyanide and Polymer-bound Imines Bioorganic & Medicinal Chemistry Letters. Aug, 2005 | Pubmed ID: 15993061 A Modification of the Hammett Equation for Predicting Ionisation Constants of P-vinyl Phenols European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jul-Aug, 2005 | Pubmed ID: 15979536 Analysis of Small Molecules by Ultra Thin-layer Chromatography-atmospheric Pressure Matrix-assisted Laser Desorption/ionization Mass Spectrometry Journal of the American Society for Mass Spectrometry. Jun, 2005 | Pubmed ID: 15907705 Recent Advances in 1,3-dipolar Cycloaddition Reactions on Solid Supports Molecular Diversity. 2005 | Pubmed ID: 15789565 On the Hydrolytic Behavior of Tinidazole, Metronidazole, and Ornidazole Journal of Pharmaceutical Sciences. Apr, 2003 | Pubmed ID: 12661060 Screening for Thermotoga maritima Membrane-Bound Pyrophosphatase Inhibitors Keni Vidilaseris*1, Niklas G. Johansson*2, Ainoleena Turku2, Alexandros Kiriazis2, Gustav Boije af Gennäs2, Jari Yli-Kauhaluoma2, Henri Xhaard2, Adrian Goldman1,3 1Research Program in Molecular and Integrative Biosciences, University of Helsinki, 2Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, 3School of Biomedical Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds JoVE 60619 Biochemistry
Screening for Thermotoga maritima Membrane-Bound Pyrophosphatase Inhibitors Keni Vidilaseris*1, Niklas G. Johansson*2, Ainoleena Turku2, Alexandros Kiriazis2, Gustav Boije af Gennäs2, Jari Yli-Kauhaluoma2, Henri Xhaard2, Adrian Goldman1,3 1Research Program in Molecular and Integrative Biosciences, University of Helsinki, 2Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, 3School of Biomedical Sciences and Astbury Centre for Structural Molecular Biology, University of Leeds JoVE 60619 Biochemistry