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Isolation and Characterization of Bone Marrow Microenvironment in Myeloid Neoplasms

November 10th, 2023
1,2, 1,3, 1,3, 1,2, 1,3,4, 1,5, 1,3
1Wilmot Cancer Institute, University of Rochester Medical Center, 2Department of Biomedical Engineering, University of Rochester, 3Department of Biomedical Genetics, University of Rochester Medical Center, 4Genomics Research Center, University of Rochester Medical Center, 5Division of Endocrinology and Metabolism, Department of Medicine, University of Rochester Medical Center

Summary
Automatic Translation

Este é apresentado um protocolo detalhado para isolar e caracterizar populações microambientais da medula óssea de modelos murinos de síndromes mielodisplásicas e leucemia mieloide aguda. Esta técnica identifica alterações no nicho da medula óssea não hematopoiética, incluindo as células endoteliais e estromais mesenquimais, com a progressão da doença.

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