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Journal / Biochemistry / Fingerprinting Cardiolipine in leukocyten door…
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Biochemistry

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JoVE Journal Biochemistry
Fingerprinting Cardiolipine in leukocyten door massaspectrometrie voor een snelle diagnose van het Barth-syndroom
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Fingerprinting Cardiolipine in leukocyten door massaspectrometrie voor een snelle diagnose van het Barth-syndroom

Article DOI: 10.3791/63552-v • 06:48 min • March 23rd, 2022
March 23rd, 2022 •
*1, *2, 2, 2
1Medical School, Swansea University, 2Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari Aldo Moro
* These authors contributed equally

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Dit protocol laat zien hoe een massaspectrometrische "vingerafdruk" van leukocyten cardiolipine kan worden verkregen voor de diagnose van het Barth-syndroom. De beoordeling van de verhoogde monolysocardiolipine tot cardiolipine ratio onderscheidt patiënten met barthsyndroom van controle hartfalen patiënten met 100% sensitiviteit en specificiteit.

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Biochemie Nummer 181
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