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Journal / Genetics / 评估和量化年龄相关性黄斑变性小鼠模型中视网膜色素上皮病理的协议…
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Genetics
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JoVE Journal Genetics
评估和量化年龄相关性黄斑变性小鼠模型中视网膜色素上皮病理的协议
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评估和量化年龄相关性黄斑变性小鼠模型中视网膜色素上皮病理的协议

Article DOI: 10.3791/64927-v • 09:24 min • March 10th, 2023
March 10th, 2023 •
1,2, 1, 3, 1,2, 3,4, 1,2
1Department of Medical Genetics, University of Wisconsin-Madison, 2McPherson Eye Research Institute, University of Wisconsin-Madison, 3Department of Ophthalmology, Duke University, 4Department of Cell Biology, Duke University

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小鼠模型可以成为研究视网膜色素上皮（RPE）生物学的有用工具。已经确定小鼠可以发展出一系列RPE病理。在这里，我们描述了一种表型方案，以使用光，透射电子和共聚焦显微镜阐明和量化小鼠的RPE病理。

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